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Authors
Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Dept. of Ayush, Patiala, IN
2 National Botanical Research Institute, Rana Pratap Marg, Lucknow, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 362-369
Abstract
The use of solid phase synthesis techniques has been explored as an alternative to conventional approaches for the synthesis of compounds used in the drug discovery process. Combinatorial chemistry now plays an important role in the lead discovery and hit optimization processes in the pharmaceutical world as well as in other areas of discovery chemistry. Now days this is an important technique for the development of different synthesis concepts that were intended to cover and explore the chemical space without having to prepare every individual compound. Solid phase synthesis technologies were developed in response to the increased screening capacities and target oriented lead finding. This article explains different linker, protecting group, cleavage methods used in solid phase synthesis, combinatorial libraries and screening system used in solid phase synthesis.
Keywords
Solid Phase Synthesis, Combinatorial Chemistry, Linker, Protecting Group.
